People vaccinated against COVID-19 may be sick…See more ​‍͏

COVID-19 vaccines in 2026 remain highly effective at reducing severe illness, hospitalization, and death, especially with updated Omicron-adapted boosters. While vaccinated individuals can still experience breakthrough infections, the overall risk of serious outcomes is significantly lower compared to the unvaccinated.

How COVID-19 Vaccines Work

  • Immune response: Vaccines train the immune system to recognize SARS-CoV-2 and mount a rapid defense.
  • Platforms: mRNA (Pfizer, Moderna), protein-based (Novavax), and adenovirus-vectored vaccines remain widely used.
  • Boosters: Updated formulations target newer variants like JN.1, improving protection against circulating strains.

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